Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations.

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作者： Cecilia,Pozzi ^[1] ; Matteo,Santucci ^[2] ; Gaetano,Marverti ^[3] ; Domenico,D'Arca ^[3] ; Lorenzo,Tagliazucchi ^[2] ; Stefania,Ferrari ^[2] ; Gaia,Gozzi ^[2] ; Lorena,Losi ^[2] ; Giusy,Tassone ^[1] ; Stefano,Mangani ^[1] ; Glauco,Ponterini ^[2] ; Maria Paola,Costi ^[2]

作者单位： Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, Via A. Moro 2, 53100 Siena, Italy. ^[1] Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy. ^[2] Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy. ^[3]

关键词 X-ray crystal structures anticancer agents drug combinations inhibition kinetics synergistic combination thymidylate synthase

DOI 10.3390/cancers13092061

PMID 33923290

发布时间 2021-05-18

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