Efficient immunogenic peptide antigen delivery to dendritic cells using an ESCRT-mediated extracellular vesicle formation method.

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第一作者： Sakika,Kimura

第一单位： Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Japan.

作者： Sakika,Kimura ^[1] ; Koki,Maeda ^[1] ; Ryuichi,Nagashima ^[2] ; Koya,Miura ^[1] ; Masashi,Arakawa ^[1] ; Hirotaka,Ebina ^[3] ; Nobuyuki,Tanaka ^[4] ; Eiji,Morita ^[5]

作者单位： Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Japan. ^[1] Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori, Japan. ^[2] Virus Vaccine Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Institute for Open and Transdisciplinary Research Initiatives, Suita, Osaka University, Osaka, Japan; Virus Vaccine Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan; The Research Foundation for Microbial Diseases of Osaka University, Suita, Osaka, Japan. ^[3] Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori, Japan; Department of Cancer Biology and Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan. ^[4] Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Japan. Electronic address: moritae@hirosaki-u.ac.jp. ^[5]

关键词 Cell-mediated immunity Cytotoxic T lymphocyte activation Endosomal sorting complexes required for transport (ESCRT)Extracellular vesicle designing Vaccine development

主题词抗原呈递(Antigen Presentation);树突细胞(Dendritic Cells);转运所需的胞内分选复合物(Endosomal Sorting Complexes Required for Transport);组织相容性抗原Ⅰ类(Histocompatibility Antigens Class I);组织相容性抗原Ⅱ类(Histocompatibility Antigens Class II);肽类(Peptides);T淋巴细胞, 细胞毒性(T-Lymphocytes, Cytotoxic)

DOI 10.1016/j.vaccine.2021.04.021

PMID 33926749

发布时间 2021-05-27

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