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A pilot study of oral treprostinil pharmacogenomics and treatment persistence in patients with pulmonary arterial hypertension.

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第一作者： James C,Coons

第一单位： University of Pittsburgh School of Pharmacy, Clinical Pharmacist, Cardiology, UPMC Presbyterian Hospital, Salk Hall, Room 727, 3501 Terrace Street, Pittsburgh, PA 15261, USA.

作者： James C,Coons ^[1] ; Karryn,Crisamore ^[2] ; Solomon,Adams ^[3] ; Ashley,Modany ^[4] ; Marc A,Simon ^[5] ; Wenchen,Zhao ^[6] ; Imam H,Shaik ^[6] ; Raman,Venkataramanan ^[6] ; Philip E,Empey ^[7]

作者单位： University of Pittsburgh School of Pharmacy, Clinical Pharmacist, Cardiology, UPMC Presbyterian Hospital, Salk Hall, Room 727, 3501 Terrace Street, Pittsburgh, PA 15261, USA. ^[1] Department of Pharmaceutical Sciences, Center for Clinical Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA. ^[2] Shenandoah University, Winchester, VA, USA. ^[3] UPMC Presbyterian Hospital, Pittsburgh, PA, USA. ^[4] Bioengineering, and Clinical Translational Science, Department of Medicine/Division of Cardiology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.;Heart and Vascular Institute, Heart Failure Research, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. ^[5] Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA. ^[6] Pharmacogenomics Center of Excellence, Institute for Personalized Medicine, Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences and the Clinical and Translational Science Institute, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA. ^[7]

关键词 personalized medicine pharmacogenomics pulmonary arterial hypertension treprostinil

医学主题词投药, 口服(Administration, Oral);依前列醇(Epoprostenol);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);遗传药理学(Pharmacogenetics);试点项目(Pilot Projects);回顾性研究(Retrospective Studies)

DOI 10.1177/17534666211013688

PMID 33929912

发布时间 2024-04-02

基金项目

P01 HL103455/HL/NHLBI NIH HHS/United States R01 AG058659/AG/NIA NIH HHS/United States TL1 TR001858/TR/NCATS NIH HHS/United States UL1 TR001857/TR/NCATS NIH HHS/United States

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