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Phosphorylated tau targeted small-molecule PROTACs for the treatment of Alzheimer's disease and tauopathies.

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第一作者： Pradeepkiran,Jangampalli Adi

第一单位： Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

作者： Pradeepkiran,Jangampalli Adi ^[1] ; P Hemachandra,Reddy ^[2]

作者单位： Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. ^[1] Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Speech, Language, and Hearing Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: Hemachandra.reddy@ttuhsc.edu. ^[2]

关键词 Alzheimer's disease Hyperphosphorylation Neurofibrillary tangles PROTACs Paired helical filament Tau protein Tauopathies