Gain and loss of function mutations in biological chemical reaction networks: a mathematical model with application to colorectal cancer cells.

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第一作者： Sara,Sommariva

第一单位： Dipartimento di Matematica, Universitá di Genova, Via Dodecaneso, 35 16146, Genoa, Italy.

作者： Sara,Sommariva ^[1] ; Giacomo,Caviglia ^[1] ; Michele,Piana ^[2]

作者单位： Dipartimento di Matematica, Universitá di Genova, Via Dodecaneso, 35 16146, Genoa, Italy. ^[1] Dipartimento di Matematica, Universitá di Genova, Via Dodecaneso, 35 16146, Genoa, Italy. piana@dima.unige.it.;CNR - SPIN GENOVA, Via Dodecaneso, 35 16146, Genoa, Italy. piana@dima.unige.it. ^[2]

关键词 Colorectal cancer cells G1-S transition point Gain of function mutations Loss of function mutations Reaction kinetics Synthetic cell biology

主题词结直肠肿瘤(Colorectal Neoplasms);计算机模拟(Computer Simulation);人类(Humans);动力学(Kinetics);模型, 生物学(Models, Biological)

DOI 10.1007/s00285-021-01607-0

PMID 33945019

发布时间 2022-02-19

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