换一批Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer's disease.
第一作者：
Priyanka Kumari,Choubey
第一单位：
Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India.
作者：
医学主题词
乙酰胆碱酯酶(Acetylcholinesterase);阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);丁酰胆碱酯酶(Butyrylcholinesterase);胆碱酯酶抑制剂(Cholinesterase Inhibitors);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);女(雌)性(Female);人类(Humans);男(雄)性(Male);迷宫学习(Maze Learning);分子结构(Molecular Structure);神经保护药(Neuroprotective Agents);恶二唑类(Oxadiazoles);肽碎片(Peptide Fragments);吡咯烷类(Pyrrolidines);大鼠(Rats);大鼠, Wistar(Rats, Wistar);构效关系(Structure-Activity Relationship)
DOI
10.1016/j.bioorg.2021.104922
PMID
33945941
发布时间
2021-10-14
- 浏览1
Bioorganic chemistry
104922页
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