首页> Journal of medicinal chemistry> Macrocyclic Peptides that Selectively Inhibit the <i>Mycobacterium tuberculosis</i> Proteasome.

Macrocyclic Peptides that Selectively Inhibit the <i>Mycobacterium tuberculosis</i> Proteasome.

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第一作者： Hao,Zhang

第一单位： Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, New York 10065, United States.

作者： Hao,Zhang ^[1] ; Hao-Chi,Hsu ^[2] ; Shoshanna C,Kahne ^[3] ; Ryoma,Hara ^[4] ; Wenhu,Zhan ^[1] ; Xiuju,Jiang ^[1] ; Kristin,Burns-Huang ^[1] ; Tierra,Ouellette ^[1] ; Toshihiro,Imaeda ^[4] ; Rei,Okamoto ^[4] ; Masanori,Kawasaki ^[4] ; Mayako,Michino ^[4] ; Tzu-Tshin,Wong ^[4] ; Akinori,Toita ^[4] ; Takafumi,Yukawa ^[4] ; Francesca,Moraca ^[5] ; Jeremie,Vendome ^[5] ; Priya,Saha ^[1] ; Kenjiro,Sato ^[4] ; Kazuyoshi,Aso ^[4] ; John,Ginn ^[4] ; Peter T,Meinke ^[4] ; Michael,Foley ^[4] ; Carl F,Nathan ^[1] ; K Heran,Darwin ^[3] ; Huilin,Li ^[2] ; Gang,Lin ^[1]

作者单位： Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, New York 10065, United States. ^[1] Department of Structural Biology, Van Andel Institute, 333 Bostwick Avenue NE, Grand Rapids, Michigan 49503, United States. ^[2] Department of Microbiology, New York University School of Medicine, 430 E. 29th Street, New York, New York 10016, United States. ^[3] Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th Street, New York, New York 10065, United States. ^[4] Schrödinger, Inc., New York, New York 10036, United States. ^[5]

医学主题词抗菌药(Anti-Bacterial Agents);药物设计(Drug Design);人类(Humans);结核分枝杆菌(Mycobacterium tuberculosis);肽类, 环(Peptides, Cyclic);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);构效关系(Structure-Activity Relationship)

DOI 10.1021/acs.jmedchem.1c00296

PMID 33949190

发布时间 2024-04-02

基金项目

R01 AI070285/AI/NIAID NIH HHS/United States R01 AI088075/AI/NIAID NIH HHS/United States R21 AI144552/AI/NIAID NIH HHS/United States T32 AI007180/AI/NIAID NIH HHS/United States R01 AI143714/AI/NIAID NIH HHS/United States

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