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PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.

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作者: Shuai,Ma [1] ; Cheng,Cao [1] ; Shiyou,Che [2] ; Yuejiao,Wang [1] ; Dongxue,Su [3] ; Shuai,Liu [1] ; Wenchen,Gong [1] ; Ling,Liu [1] ; Jixue,Sun [2] ; Jiao,Zhao [1] ; Qian,Wang [1] ; Nan,Song [1] ; Tong,Ge [1] ; Qiushi,Guo [1] ; Shanshan,Tian [1] ; Charlie Degui,Chen [4] ; Tao,Zhang [1] ; Ju,Wang [1] ; Xiang,Ding [5] ; Fuquan,Yang [5] ; Guoguang,Ying [1] ; Jie,Yang [1] ; Kai,Zhang [1] ; Yi,Zhu [1] ; Zhi,Yao [6] ; Na,Yang [7] ; Lei,Shi [6]
作者单位: State Key Laboratory of Experimental Hematology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300070, China. [1] State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Key Laboratory of Medical Data Analysis and Statistical Research of Tianjin, Nankai University, 300353 Tianjin, China. [2] State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. [3] State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. [4] Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. [5] State Key Laboratory of Experimental Hematology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300070, China. shilei@tmu.edu.cn yangnanku@nankai.edu.cn yaozhi@tmu.edu.cn. [6] State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Key Laboratory of Medical Data Analysis and Statistical Research of Tianjin, Nankai University, 300353 Tianjin, China. shilei@tmu.edu.cn yangnanku@nankai.edu.cn yaozhi@tmu.edu.cn. [7]
DOI 10.1126/sciadv.abf7684
PMID 33952527
发布时间 2022-04-15
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2021年7卷19期

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