Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer.

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第一作者： Ran,Li

第一单位： Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.

作者： Ran,Li ^[1] ; Thomas S C,Ng ^[2] ; Stephanie J,Wang ^[1] ; Mark,Prytyskach ^[2] ; Christopher B,Rodell ^[1] ; Hannes,Mikula ^[3] ; Rainer H,Kohler ^[1] ; Michelle A,Garlin ^[1] ; Douglas A,Lauffenburger ^[4] ; Sareh,Parangi ^[1] ; Daniela M,Dinulescu ^[5] ; Nabeel,Bardeesy ^[1] ; Ralph,Weissleder ^[1] ; Miles A,Miller ^[3]

作者单位： Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA. ^[1] Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. ^[2] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[3] School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA. ^[4] Institute of Applied Synthetic Chemistry, Vienna University of Technology (TU Wien), Vienna, Austria. ^[5] Department of Surgery, Massachusetts General Hospital, Boston, MA, USA. ^[6] Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ^[7] MGH Cancer Center, Massachusetts General Hospital Research Institute, Boston, MA, USA. ^[8] Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA. rweissleder@mgh.harvard.edu. ^[9] Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. rweissleder@mgh.harvard.edu. ^[10] Department of Systems Biology, Harvard Medical School, Boston, MA, USA. rweissleder@mgh.harvard.edu. ^[11] Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA. miles.miller@mgh.harvard.edu. ^[12] Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. miles.miller@mgh.harvard.edu. ^[13]