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Mendelian randomisation for mediation analysis: current methods and challenges for implementation.

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第一作者： Alice R,Carter

第一单位： MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. alice.carter@bristol.ac.uk.;Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK. alice.carter@bristol.ac.uk.

作者： Alice R,Carter ^[1] ; Eleanor,Sanderson ^[2] ; Gemma,Hammerton ^[3] ; Rebecca C,Richmond ^[2] ; George,Davey Smith ^[4] ; Jon,Heron ^[3] ; Amy E,Taylor ^[4] ; Neil M,Davies ^[5] ; Laura D,Howe ^[2]

作者单位： MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. alice.carter@bristol.ac.uk.;Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK. alice.carter@bristol.ac.uk. ^[1] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK. ^[2] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.;Centre for Academic Mental Health, University of Bristol, Bristol, UK. ^[3] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.;National Institute for Health Research Biomedical Research Centre At the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK. ^[4] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.;K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. ^[5]

关键词 Mediation analysis Mendelian randomisation Multivariable Mendelian randomisation Two-step Mendelian randomisation

医学主题词因果律(Causality);基因多效性(Genetic Pleiotropy);遗传变异(Genetic Variation);全基因组关联研究(Genome-Wide Association Study);人类(Humans);孟德尔随机化分析(Mendelian Randomization Analysis)

DOI 10.1007/s10654-021-00757-1

PMID 33961203

发布时间 2025-05-30

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