A 6-month inhalation toxicology study in Apoe<sup>-/-</sup> mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract.

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作者： Ee Tsin,Wong ^[1] ; Justyna,Szostak ^[2] ; Bjoern,Titz ^[3] ; Tom,Lee ^[1] ; Sin Kei,Wong ^[1] ; Oksana,Lavrynenko ^[3] ; Celine,Merg ^[3] ; Maica,Corciulo ^[3] ; Jovan,Simicevic ^[3] ; Mehdi,Auberson ^[3] ; Dariusz,Peric ^[3] ; Remi,Dulize ^[3] ; David,Bornand ^[3] ; Guo Jie,Loh ^[1] ; Kyeonghee Monica,Lee ^[4] ; Jingjie,Zhang ^[4] ; John H,Miller ^[4] ; Walter K,Schlage ^[5] ; Emmanuel,Guedj ^[3] ; Thomas,Schneider ^[3] ; Blaine,Phillips ^[1] ; Patrice,Leroy ^[3] ; Mohamed Amin,Choukrallah ^[3] ; Nicolas,Sierro ^[3] ; Ansgar,Buettner ^[6] ; Yang,Xiang ^[3] ; Arkadiusz,Kuczaj ^[3] ; Nikolai V,Ivanov ^[3] ; Karsta,Luettich ^[3] ; Patrick,Vanscheeuwijck ^[3] ; Manuel C,Peitsch ^[3] ; Julia,Hoeng ^[3]

作者单位： PMI R&D, Philip Morris International Research Laboratories Pte. Ltd, Science Park II, Singapore, 117406, Singapore. ^[1] PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, 2000, Neuchâtel, Switzerland. Justyna.Szostak@pmi.com. ^[2] PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, 2000, Neuchâtel, Switzerland. ^[3] Altria Client Services LLC, 601 East Jackson Street, Richmond, VA, 23219, USA. ^[4] , Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany. ^[5] Histovia GmbH, Schöne Aussicht 5, 51491, Overath, Germany. ^[6]

关键词 COPD Electronic cigarette Emphysema Inflammation Smoking