Parental genome unification is highly error-prone in mammalian embryos.

导出 OA

翻译打印收藏纠错

作者： Tommaso,Cavazza ^[1] ; Yuko,Takeda ^[2] ; Antonio Z,Politi ^[1] ; Magomet,Aushev ^[2] ; Patrick,Aldag ^[3] ; Clara,Baker ^[4] ; Meenakshi,Choudhary ^[5] ; Jonas,Bucevičius ^[1] ; Gražvydas,Lukinavičius ^[1] ; Kay,Elder ^[4] ; Martyn,Blayney ^[4] ; Andrea,Lucas-Hahn ^[3] ; Heiner,Niemann ^[3] ; Mary,Herbert ^[6] ; Melina,Schuh ^[7]

作者单位： Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany. ^[1] Wellcome Centre for Mitochondrial Research, Biosciences Institute, Newcastle University, NE1 4EP Newcastle upon Tyne, UK. ^[2] Institute of Farm Animal Genetics, Biotechnology, Friedrich-Loeffler-Institute, Mariensee, 31535 Neustadt, Germany. ^[3] Bourn Hall Clinic, CB23 2TN Cambridge, UK. ^[4] Newcastle Fertility Centre at Life, Newcastle upon Tyne Hospitals NHS Foundation Trust, NE1 4EP Newcastle upon Tyne, UK. ^[5] Wellcome Centre for Mitochondrial Research, Biosciences Institute, Newcastle University, NE1 4EP Newcastle upon Tyne, UK; Newcastle Fertility Centre at Life, Newcastle upon Tyne Hospitals NHS Foundation Trust, NE1 4EP Newcastle upon Tyne, UK. ^[6] Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany. Electronic address: melina.schuh@mpibpc.mpg.de. ^[7]

关键词 aneuploidy centrosomes chromosome segregation dynein fertilization genome organization human embryo microtubules nuclear pore complex spindle