Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery.

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作者： Jördis,Klose ^[1] ; Melanie,Pahl ^[1] ; Kristina,Bartmann ^[1] ; Farina,Bendt ^[1] ; Jonathan,Blum ^[2] ; Xenia,Dolde ^[2] ; Nils,Förster ^[3] ; Anna-Katharina,Holzer ^[2] ; Ulrike,Hübenthal ^[1] ; Hagen Eike,Keßel ^[1] ; Katharina,Koch ^[1] ; Stefan,Masjosthusmann ^[1] ; Sabine,Schneider ^[1] ; Lynn-Christin,Stürzl ^[1] ; Selina,Woeste ^[1] ; Andrea,Rossi ^[1] ; Adrian,Covaci ^[4] ; Mamta,Behl ^[5] ; Marcel,Leist ^[2] ; Julia,Tigges ^[1] ; Ellen,Fritsche ^[6]

作者单位： IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225, Duesseldorf, NRW, Germany. ^[1] Department of Biology, University of Konstanz, Universitätsstraße 10, 78464, Konstanz, BW, Germany. ^[2] Faculty for Biology and Biotechnology, Bioinformatics Group, RUB - Ruhr University Bochum, Bochum, Germany. ^[3] Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. ^[4] Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, 27709, USA. ^[5] IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225, Duesseldorf, NRW, Germany. ellen.fritsche@uni-duesseldorf.de. ^[6] Medical Faculty, Heinrich-Heine-University, Universitätsstraße 1, 40225, Duesseldorf, NRW, Germany. ellen.fritsche@uni-duesseldorf.de. ^[7]

关键词 3D in vitro model Developmental neurotoxicity Flame retardants Hazard assessment Human cell–based testing battery New approach methodologies