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首页> The Journal of experimental medicine> DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells.

DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells.

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作者： Jung-Yeon,Lim ^[1] ; Sascha H,Duttke ^[2] ; Turner S,Baker ^[1] ; Jihye,Lee ^[1] ; Kristyne J,Gambino ^[1] ; Nicholas J,Venturini ^[1] ; Jessica Sook Yuin,Ho ^[3] ; Simin,Zheng ^[3] ; Yesai S,Fstkchyan ^[3] ; Vinodh,Pillai ^[4] ; David C,Fajgenbaum ^[5] ; Ivan,Marazzi ^[3] ; Christopher,Benner ^[2] ; Minji,Byun ^[1]

作者单位： Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY. ^[1] Department of Medicine, University of California, San Diego, La Jolla, CA. ^[2] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY. ^[3] Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA. ^[4] Department of Medicine, University of Pennsylvania, Philadelphia, PA. ^[5] Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. ^[6]

主题词细胞, 培养的(Cells, Cultured);DNA甲基化(DNA Methylation);基因表达(Gene Expression);单倍剂量不足(Haploinsufficiency);人类(Humans);免疫系统(Immune System);突变(Mutation);调控序列, 核酸(Regulatory Sequences, Nucleic Acid)

DOI 10.1084/jem.20202733

PMID 33970190

发布时间 2024-03-29

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The Journal of experimental medicine

The Journal of experimental medicine

2021年218卷7期

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