High-resolution targeted bisulfite sequencing reveals blood cell type-specific DNA methylation patterns in IL13 and ORMDL3.

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作者： Cilla,Söderhäll ^[1] ; Lovisa E,Reinius ^[2] ; Pertteli,Salmenperä ^[3] ; Massimiliano,Gentile ^[4] ; Nathalie,Acevedo ^[5] ; Jon R,Konradsen ^[5] ; Björn,Nordlund ^[6] ; Gunilla,Hedlin ^[7] ; Annika,Scheynius ^[8] ; Samuel,Myllykangas ^[9] ; Juha,Kere ^[8]

作者单位： Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. cilla.soderhall@ki.se. ^[1] Department of Women's and Children's Health, Karolinska Institutet, Bioclinicum J9:30, Visionsgatan 4, 171 64, Stockholm, Sweden. cilla.soderhall@ki.se. ^[2] Department of Pediatric Allergy and Pulmonology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. cilla.soderhall@ki.se. ^[3] Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. ^[4] Blueprint Genetics, Helsinki, Finland. ^[5] Department of Clinical Science and Education, Karolinska Institutet, and Sachs' Children and Youth Hospital, Södersjukhuset, 118 83, Stockholm, Sweden. ^[6] Institute for Immunological Research, University of Cartagena, Cartagena, Colombia. ^[7] Department of Women's and Children's Health, Karolinska Institutet, Bioclinicum J9:30, Visionsgatan 4, 171 64, Stockholm, Sweden. ^[8] Department of Pediatric Allergy and Pulmonology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. ^[9] Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden. ^[10] Folkhälsan Research Center, Helsinki, Finland. ^[11] Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland. ^[12]

关键词 450?k Asthma Bs-OS-sequencing CpG sites DNA methylation Epigenetic profiling IL13 ORMDL3