Pen-2 Negatively Regulates the Differentiation of Oligodendrocyte Precursor Cells into Astrocytes in the Central Nervous System.

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作者： Jinxing,Hou ^[1] ; Huiru,Bi ^[1] ; Zhuoyang,Ye ^[1] ; Wenhui,Huang ^[2] ; Gang,Zou ^[3] ; Xiaochuan,Zou ^[1] ; Yun Stone,Shi ^[1] ; Ying,Shen ^[4] ; Quanhong,Ma ^[5] ; Frank,Kirchhoff ^[2] ; Yimin,Hu ^[6] ; Guiquan,Chen ^[7]

作者单位： State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China. ^[1] Department of Molecular Physiology, Center for Integrative Physiology and Molecular Medicine, University of Saarland, Homburg, D-66421, Germany. ^[2] Department of General Surgery, Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen, 518000, China. ^[3] Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China. ^[4] Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Institute of Neuroscience, Second Affiliated Hospital, Soochow University, Suzhou, 215123, China. ^[5] Department of Anesthesiology, Second Affiliated Changzhou People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, China guyueym@njmu.edu.cn chenguiquan@nju.edu.cn. ^[6] State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China guyueym@njmu.edu.cn chenguiquan@nju.edu.cn. ^[7]

关键词 Presenilin enhancer 2 astrocytes astrogliogenesis oligodendrocyte differentiation oligodendrocyte precursor cells