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Pathomechanisms of ALS8: altered autophagy and defective RNA binding protein (RBP) homeostasis due to the VAPB P56S mutation.

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第一作者: Priyanka,Tripathi
第一单位: Institute of Neuropathology, RWTH Aachen University Medical School, Pauwelsstr. 30, 52074, Aachen, Germany.;EURON - European Graduate School of Neuroscience, Maastricht, The Netherlands.
作者单位: Institute of Neuropathology, RWTH Aachen University Medical School, Pauwelsstr. 30, 52074, Aachen, Germany.;EURON - European Graduate School of Neuroscience, Maastricht, The Netherlands. [1] Institute of Neuropathology, RWTH Aachen University Medical School, Pauwelsstr. 30, 52074, Aachen, Germany. [2] Institute of Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Pauwelsstr. 30, 52074, Aachen, Germany. [3] Institute of Neuropathology, RWTH Aachen University Medical School, Pauwelsstr. 30, 52074, Aachen, Germany.;Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. [4] Institute of Biochemistry and Molecular Biology, RWTH Aachen University, 52074, Aachen, Germany.;Confocal Microscopy Facility, Interdisciplinary Center for Clinical Research IZKF, RWTH Aachen University, 52074, Aachen, Germany. [5] Amsterdam UMC, University of Amsterdam, Department of (Neuro) Pathology, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. [6] Translational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology and Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, 18147, Rostock, Germany. [7] Translational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology and Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, 18147, Rostock, Germany.;German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, 18147, Rostock, Germany. [8] EURON - European Graduate School of Neuroscience, Maastricht, The Netherlands.;Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. [9] Hämatopathologie Lübeck, Reference Centre for Lymph Node Pathology and Haematopathology, University Hospital of Schleswig-Holstein, Lübeck, Germany. [10] Institute für Neuropathologie, Bremen-Mitte, Bremen, Germany. [11] Department of Neuroscience, Erasmus MC, Rotterdam, 3015, GD, The Netherlands. [12] Institute of Neuropathology, RWTH Aachen University Medical School, Pauwelsstr. 30, 52074, Aachen, Germany. agoswami@ukaachen.de. [13]
DOI 10.1038/s41419-021-03710-y
PMID 33972508
发布时间 2023-02-01
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