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Correction of the pathogenic mutation in TGM1 gene by adenine base editing in mutant embryos.

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作者: Lu,Dang [1] ; Xueliang,Zhou [2] ; Xiufang,Zhong [3] ; Wenxia,Yu [4] ; Shisheng,Huang [4] ; Hanyan,Liu [2] ; Yuanyuan,Chen [3] ; Wuwen,Zhang [3] ; Lihua,Yuan [3] ; Lei,Li [2] ; Xingxu,Huang [4] ; Guanglei,Li [5] ; Jianqiao,Liu [6] ; Guoqing,Tong [7]
作者单位: Department of Obstetrics and Gynecology, Center of Reproductive Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. [1] Department of Obstetrics and Gynecology, Center of Reproductive Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Key Laboratory for Reproductive Medicine of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. [2] Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. [3] Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. [4] Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: ligl@shanghaitech.edu.cn. [5] Department of Obstetrics and Gynecology, Center of Reproductive Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Key Laboratory for Reproductive Medicine of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address: liujqssz@gzhmu.edu.cn. [6] Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: drivftongguoqing@shutcm.edu.cn. [7]
DOI 10.1016/j.ymthe.2021.05.007
PMID 33974999
发布时间 2024-02-21
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Molecular therapy : the journal of the American Society of Gene Therapy

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