Relevance of production method on the physical stability and in vitro biopharmaceutical performances of olanzapine orodispersible film.

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作者： Francesca,Selmin ^[1] ; Garba M,Khalid ^[1] ; Umberto M,Musazzi ^[1] ; Francesco,Demartin ^[2] ; Paola,Minghetti ^[1] ; Francesco,Cilurzo ^[3]

作者单位： Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via G. Colombo, 71 - 20133 Milan, Italy. ^[1] Department of Chemistry, Università degli Studi di Milano, Via Golgi, 19 - 20133 Milan, Italy. ^[2] Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via G. Colombo, 71 - 20133 Milan, Italy. Electronic address: francesco.cilurzo@unimi.it. ^[3]

关键词 Dissolution Hot-melt ram-extrusion Maltodextrins Personalize therapy Polymorphism Printing

主题词投药, 口服(Administration, Oral);动物(Animals);生物利用度(Biological Availability);生物制品(Biological Products);男(雄)性(Male);溶解度(Solubility);溶剂(Solvents)

DOI 10.1016/j.ijpharm.2021.120697

PMID 33984453

发布时间 2022-08-12

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