Interactions of core cross-linked poly(2-oxazoline) and poly(2-oxazine) micelles with immune cells in human blood.

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作者： Meike N,Leiske ^[1] ; May,Lai ^[1] ; Thakshila,Amarasena ^[2] ; Thomas P,Davis ^[3] ; Kristofer J,Thurecht ^[4] ; Stephen J,Kent ^[5] ; Kristian,Kempe ^[6]

作者单位： ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, and Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. ^[1] ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, The University of Melbourne, Melbourne, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, 3000, Australia. ^[2] ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, and Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia; Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Centre of Excellence in Convergent Bio-Nano Science & Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, QLD, 4072, Australia. ^[3] Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Centre of Excellence in Convergent Bio-Nano Science & Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, QLD, 4072, Australia. ^[4] ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, The University of Melbourne, Melbourne, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, 3000, Australia; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University, Melbourne, VIC, 3800, Australia. ^[5] ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, and Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia; Materials Science and Engineering, Monash University, Clayton, VIC, 3800, Australia. Electronic address: kristian.kempe@monash.edu. ^[6]

关键词 Core cross-linked micelle Cyclic imino ether Emulsion polymerisation Immune cell interaction RAFT polymerisation Stealth effect

主题词人类(Humans);微胶粒(Micelles);恶嗪类(Oxazines);恶唑类(Oxazoles);聚合(Polymerization);聚合物(Polymers)

DOI 10.1016/j.biomaterials.2021.120843

PMID 33984635

发布时间 2021-06-25

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