Aspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells.

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作者： Selda,Gezginci-Oktayoglu ^[1] ; Merve,Ercin ^[2] ; Serap,Sancar ^[3] ; Ertan,Celik ^[4] ; Meral,Koyuturk ^[5] ; Sema,Bolkent ^[6] ; Sehnaz,Bolkent ^[3]

作者单位： Istanbul University, Faculty of Science, Biology Department, Molecular Biology Section, Istanbul, Turkey. Electronic address: selgez@istanbul.edu.tr. ^[1] Istanbul University, Faculty of Science, Biology Department, Molecular Biology Section, Istanbul, Turkey; Istanbul University, Institute of Science, Biology Section, Molecular Biology Program, Istanbul, Turkey. ^[2] Istanbul University, Faculty of Science, Biology Department, Molecular Biology Section, Istanbul, Turkey. ^[3] Istanbul University, Institute of Science, Biology Section, Molecular Biology Program, Istanbul, Turkey. ^[4] Istanbul University-Cerrahpasa, Medicine Faculty, Department of Histology and Embryology, Istanbul, Turkey. ^[5] Istanbul University-Cerrahpasa, Medicine Faculty, Department of Medical Biology, Istanbul, Turkey. ^[6]

关键词 Aspartame Cancer stem cell GLI1 Glucose NICD T1R1 p21

主题词腺癌(Adenocarcinoma);阿司帕坦(Aspartame);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);葡萄糖(Glucose);人类(Humans);肿瘤干细胞(Neoplastic Stem Cells);胰腺肿瘤(Pancreatic Neoplasms);受体, G-蛋白偶联(Receptors, G-Protein-Coupled)

DOI 10.1016/j.fct.2021.112264

PMID 33992720

发布时间 2021-10-04

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Food and chemical toxicology

2021年153卷

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Aspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells.

Food and chemical toxicology

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Aspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells.

Food and chemical toxicology

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Food and chemical toxicology

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