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首页> European journal of medicinal chemistry> Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors.

Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors.

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作者： Tao,Liang ^[1] ; Junxin,Xue ^[1] ; Zefu,Yao ^[1] ; Yang,Ye ^[1] ; Xinying,Yang ^[1] ; Xuben,Hou ^[1] ; Hao,Fang ^[2]

作者单位： Department of Medicinal Chemistry and Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44, West Wenhua Road, 250012, Jinan, Shandong, PR China. ^[1] Department of Medicinal Chemistry and Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44, West Wenhua Road, 250012, Jinan, Shandong, PR China. Electronic address: haofangcn@sdu.edu.cn. ^[2]

关键词 Anti-proliferative Apoptosis HDAC6 selective inhibitor Structure optimization

主题词细胞增殖(Cell Proliferation);细胞存活(Cell Survival);细胞, 培养的(Cells, Cultured);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);人类(Humans);咪唑啉啶类(Imidazolidines);分子结构(Molecular Structure);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2021.113526

PMID 33992929

发布时间 2021-08-06

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European journal of medicinal chemistry

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