换一批
换一批<i>In vivo</i> testing of mucus-permeating nanoparticles for oral insulin delivery using <i>Caenorhabditis elegans</i> as a model under hyperglycemic conditions.
作者：
关键词
1H NMR, 1H nuclear magnetic resonanceBiodistributionCaenorhabditis elegansDAPI, 4?,6-diamidino-2-phenylindoleDeff, effective diffusion coefficientEDC, N-(3-di-methylaminopropyl)-N?-ethylcarbodiimideEpitheliumFT-IR, Fourier transform infrared spectroscopyFUdR, 5-fluoro-2′-deoxyuridineGIT, gastrointestinal tractH2DCF-DA, 2,7′-dichlorodihydro fluorescein diacetateHPLC, high-performance liquid chromatographyI, insulinIIS, insulin/IGF-1 signalingInsulinLifespanMSD, mean square displacementMucus-permeatingNGM, nematode growth mediumNPs, nanoparticlesNanoparticlesORL, orlistatOral deliveryPBST, phosphate-buffered saline with tritonPDI, polydispersity indexPEG, poly(ethylene glycol)PPA, PEG-poly(anhydride) conjugatePPA-NPs, PEG-poly(anhydride)-coated zein nanoparticlesROSROS, reactive oxygen speciesSEM, scanning electron microscopySOD, superoxide dismutaseTHF, tetrahydrofuranZein
DOI
10.1016/j.apsb.2021.02.020
PMID
33996411
发布时间
2022-02-18
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Acta pharmaceutica Sinica. B
2021年11卷4期
989-1002页
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