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CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity.

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作者单位: Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. [1] Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia. [2] Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. [3] Translational Oncology Laboratory, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain. [4] CIBERONC CB16/12/00398, La Paz University Hospital, Madrid, Spain. [5] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. [6] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. [7] Institute for Bioengineering of Catalonia, Barcelona, Spain. [8] Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. [9] Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA. [10] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. [11] Istituto Italiano di Tecnologia (IIT), Genoa, Italy. [12] Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA. [13] Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA. [14] Centre for Cancer Research, University of Melbourne, Parkville, Victoria, Australia. [15] Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. Henry_Long@dfci.harvard.edu. [16] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Henry_Long@dfci.harvard.edu. [17] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Jean_Zhao@dfci.harvard.edu. [18] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Jean_Zhao@dfci.harvard.edu. [19] The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Jean_Zhao@dfci.harvard.edu. [20] Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. shom.goel@petermac.org. [21] Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia. shom.goel@petermac.org. [22] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. shom.goel@petermac.org. [23]
DOI 10.1038/s43018-020-00135-y
PMID 33997789
发布时间 2024-01-11
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Nature cancer

Nature cancer

2021年2卷1期

34-48页

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