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首页> The Journal of nutritional biochemistry> PAR2 promotes high-fat diet-induced hepatic steatosis by inhibiting AMPK-mediated autophagy.

PAR2 promotes high-fat diet-induced hepatic steatosis by inhibiting AMPK-mediated autophagy.

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作者： Byeong Moo,Kim ^[1] ; Dae Hyun,Kim ^[1] ; Yeo Jin,Park ^[2] ; Sugyeong,Ha ^[1] ; Yeon Ja,Choi ^[3] ; Hak Sun,Yu ^[4] ; Ki Wung,Chung ^[5] ; Hae Young,Chung ^[6]

作者单位： Department of Pharmacy, Pusan National University, Busan, Republic of Korea. ^[1] Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Republic of Korea; Korean Convergence Medicine, University of Science and Technology, Daejeon 34054, Republic of Korea. ^[2] Department of Biopharmaceutical Engineering, Division of Chemistry and Biotechnology, Dongguk University, Gyeongju, Republic of Korea. ^[3] Department of Parasitology and Tropical Medicine, School of Medicine, Pusan National University, Yangsan, Republic of Korea. ^[4] Department of Pharmacy, Pusan National University, Busan, Republic of Korea. Electronic address: kieungc@pusan.ac.kr. ^[5] Department of Pharmacy, Pusan National University, Busan, Republic of Korea. Electronic address: hyjung@pusan.ac.kr. ^[6]

关键词 AMPK Autophagy CAMKKβ Hepatic steatosis PAR2 β-arrestin-2

主题词腺苷酸激酶(Adenylate Kinase);动物(Animals);自噬(Autophagy);膳食脂肪类(Dietary Fats);女(雌)性(Female);基因表达调控(Gene Expression Regulation);Hep G2细胞(Hep G2 Cells);肝细胞(Hepatocytes);人类(Humans);脂类代谢(Lipid Metabolism);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);受体, PAR-2(Receptor, PAR-2);增量调节(Up-Regulation)

DOI 10.1016/j.jnutbio.2021.108769

PMID 34000413

发布时间 2021-09-16

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The Journal of nutritional biochemistry

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