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Methotrexate polyglutamate quantification for clinical application in patients with pediatric acute lymphoblastic leukemia in association with genetic polymorphisms.

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第一作者： Rihwa,Choi

第一单位： Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Gyeonggi, Republic of Korea.

作者： Rihwa,Choi ^[1] ; Mi Ryung,Chun ^[2] ; Jisook,Park ^[3] ; Hojeong,Won ^[4] ; Seonwoo,Kim ^[4] ; Ji Won,Lee ^[5] ; Hee Young,Ju ^[6] ; Hee Won,Cho ^[6] ; Ju Kyung,Hyun ^[6] ; Hong Hoe,Koo ^[6] ; Eun Sang,Yi ^[7] ; Soo-Youn,Lee ^[8]

作者单位： Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Gyeonggi, Republic of Korea. ^[1] Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. ^[2] Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. ^[3] Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea. ^[4] Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: leejw.lee@samsung.com. ^[5] Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. ^[6] Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea. ^[7] Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Health Science and Technology, Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea. Electronic address: suddenbz@skku.edu. ^[8]

关键词 Acute lymphoblastic leukemia Methotrexate Methotrexate polyglutamates Tandem mass spectrometry Therapeutic drug monitoring

医学主题词儿童(Child);人类(Humans);甲氨蝶呤(Methotrexate);聚谷氨酸(Polyglutamic Acid);多态现象, 遗传(Polymorphism, Genetic);前体细胞淋巴母细胞白血病淋巴瘤(Precursor Cell Lymphoblastic Leukemia-Lymphoma)

DOI 10.1016/j.jpba.2021.114124

PMID 34000579

发布时间 2021-06-17

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