Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures.

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作者： Donald V,Bradshaw ^[1] ; Andrew K,Knutsen ^[2] ; Alexandru,Korotcov ^[3] ; Genevieve M,Sullivan ^[4] ; Kryslaine L,Radomski ^[3] ; Bernard J,Dardzinski ^[4] ; Xiaomei,Zi ^[2] ; Dennis P,McDaniel ^[2] ; Regina C,Armstrong ^[4]

作者单位： Graduate Program in Neuroscience, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. ^[1] Department of Anatomy, Physiology and Genetics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA. ^[2] Department of Radiology and Radiological Sciences, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. ^[3] Center for Neuroscience and Regenerative Medicine, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. ^[4] Center for Scientific Review, National Institutes of Health, Bethesda, MD, USA. ^[5] Biomedical Instrumentation Center, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. ^[6] Graduate Program in Neuroscience, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. regina.armstrong@usuhs.edu. ^[7] Department of Anatomy, Physiology and Genetics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA. regina.armstrong@usuhs.edu. ^[8] Center for Neuroscience and Regenerative Medicine, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. regina.armstrong@usuhs.edu. ^[9]

关键词 Chronic traumatic brain injury Corpus callosum atrophy Magnetic resonance imaging SARM1 Sterile alpha and Toll White matter interleukin-1 receptor containing motif 1

主题词动物(Animals);Armadillo域蛋白质类(Armadillo Domain Proteins);轴突(Axons);细胞支架蛋白质类(Cytoskeletal Proteins);弥散张量成像(Diffusion Tensor Imaging);女(雌)性(Female);基因沉默(Gene Silencing);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);神经变性(Nerve Degeneration);治疗结果(Treatment Outcome)

DOI 10.1186/s40478-021-01193-8

PMID 34001261

发布时间 2021-12-14

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Acta neuropathologica communications

2021年9卷1期

89页

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Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures.

Acta neuropathologica communications

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Acta neuropathologica communications

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Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures.

Acta neuropathologica communications

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Acta neuropathologica communications

相关期刊

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