换一批Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.
第一作者：
Vincent,Damotte
第一单位：
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
作者：
Vincent,Damotte [1]
;
Sven J,van der Lee [2]
;
Vincent,Chouraki [3]
;
Benjamin,Grenier-Boley [1]
;
Jeannette,Simino [4]
;
Hieab,Adams [5]
;
Giuseppe,Tosto [6]
;
Charles,White [7]
;
Natalie,Terzikhan [8]
;
Carlos,Cruchaga [9]
;
Maria J,Knol [10]
;
Shuo,Li [11]
;
Susanna,Schraen [12]
;
Megan L,Grove [13]
;
Claudia,Satizabal [14]
;
Najaf,Amin [10]
;
Claudine,Berr [15]
;
Steven,Younkin [16]
;
Alzheimer's Disease Neuroimaging Initiative [1]
;
Rebecca F,Gottesman [17]
;
Luc,Buée [18]
;
Alexa,Beiser [19]
;
David S,Knopman [20]
;
Andre,Uitterlinden [21]
;
Charles,DeCarli [22]
;
Jan,Bressler [13]
;
Anita,DeStefano [19]
;
Jean-François,Dartigues [23]
;
Qiong,Yang [11]
;
Eric,Boerwinkle [24]
;
Christophe,Tzourio [23]
;
Myriam,Fornage [25]
;
M Arfan,Ikram [5]
;
Philippe,Amouyel [1]
;
Phil,de Jager [26]
;
Christiane,Reitz [27]
;
Thomas H,Mosley [28]
;
Jean-Charles,Lambert [1]
;
Sudha,Seshadri [29]
;
Cornelia M,van Duijn [30]
作者单位：
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
[1]
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.;Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
[2]
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.;Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
[3]
Gertrude C. Ford MIND Center, Department of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA.
[4]
Departments of Epidemiology, Neurology, and Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
[5]
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.
[6]
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.;Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
[7]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
[8]
Department of Psychiatry, Washington University in St. Louis, Saint Louis, Missouri, USA.
[9]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
[10]
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.;The Framingham Heart Study, Framingham, Massachusetts, USA.
[11]
Université Lille, CHU-Lille, Inserm, UF de Neurobiologie, CBPG, Lille, France.
[12]
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
[13]
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.;The Framingham Heart Study, Framingham, Massachusetts, USA.
[14]
INSERM U1061, University of Montpellier, Montpellier, France.
[15]
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
[16]
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.;Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
[17]
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.;Institut National de la Santé et de la Recherche Medicale (INSERM, Université de Lille, Lille, France.
[18]
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.;The Framingham Heart Study, Framingham, Massachusetts, USA.
[19]
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
[20]
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
[21]
Department of Neurology, University of California at Davis, Davis, California, USA.
[22]
Bordeaux Population Health Research Center, INSERM, UMR1219, Bordeaux University, Bordeaux, France.
[23]
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.;Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
[24]
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.;Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
[25]
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.;Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.;Center for Translational & Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, New York, USA.
[26]
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.;Department of Neurology, Columbia University, New York, New York, USA.;Department of Epidemiology, Columbia University, New York, New York, USA.
[27]
Department of Medicine, Gertrude C. Ford MIND Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
[28]
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.;The Framingham Heart Study, Framingham, Massachusetts, USA.;Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, Texas, USA.
[29]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Nuffield Department of Population Health, University of Oxford, Oxford, UK.
[30]
医学主题词
阿尔茨海默病(Alzheimer Disease);淀粉样蛋白(Amyloid);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);载脂蛋白E类(Apolipoproteins E);天冬氨酸内肽酶类(Aspartic Acid Endopeptidases);脑(Brain);全基因组关联研究(Genome-Wide Association Study);人类(Humans);正电子发射断层显像术(Positron-Emission Tomography);早老素2(Presenilin-2)
DOI
10.1002/alz.12333
PMID
34002480
发布时间
2023-11-08
- 浏览4
Alzheimer's & dementia
Alzheimer's & dementia
1663-1674页
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