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Differences in Vaginal Microbiota, Host Transcriptome, and Proteins in Women With Bacterial Vaginosis Are Associated With Metronidazole Treatment Response.

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第一作者： Joyce,Serebrenik

第一单位： Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.

作者： Joyce,Serebrenik ^[1] ; Tao,Wang ^[2] ; Richard,Hunte ^[1] ; Sujatha,Srinivasan ^[3] ; Jessica,McWalters ^[4] ; Gregory K,Tharp ^[5] ; Steven E,Bosinger ^[6] ; Tina L,Fiedler ^[3] ; Jessica M,Atrio ^[7] ; Kerry,Murphy ^[4] ; Rebecca,Barnett ^[4] ; Laurie R,Ray ^[4] ; Meighan L,Krows ^[8] ; David N,Fredricks ^[3] ; Elizabeth,Irungu ^[9] ; Kenneth,Ngure ^[9] ; Nelly,Mugo ^[9] ; Jeanne,Marrazzo ^[10] ; Marla J,Keller ^[4] ; Betsy C,Herold ^[11]

作者单位： Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA. ^[1] Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA. ^[2] Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. ^[3] Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. ^[4] Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Atlanta, Georgia, USA. ^[5] Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Atlanta, Georgia, USA.;Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, USA.;Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. ^[6] Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York, USA. ^[7] Department of Global Health, University of Washington, Seattle, Washington, USA. ^[8] Department of Medicine, Center for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. ^[9] School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. ^[10] Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.;Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA. ^[11]

关键词 bacterial vaginosis chemokines ectocervical transcriptome metronidazole vaginal microbiota

医学主题词青少年(Adolescent);成年人(Adult);细菌(Bacteria);子宫颈(Cervix Uteri);细胞因子类(Cytokines);DNA, 细菌(DNA, Bacterial);女(雌)性(Female);人类(Humans);肯尼亚(Kenya);甲硝唑(Metronidazole);中年人(Middle Aged);聚合酶链反应(Polymerase Chain Reaction);RNA, 核糖体, 16S(RNA, Ribosomal, 16S);序列分析, DNA(Sequence Analysis, DNA);治疗结果(Treatment Outcome);阴道(Vagina);阴道病, 细菌性(Vaginosis, Bacterial)

DOI 10.1093/infdis/jiab266

PMID 34003290

发布时间 2022-05-19

基金项目

R01 AI134367/AI/NIAID NIH HHS/United States U19 AI103461/AI/NIAID NIH HHS/United States P51 OD011132/OD/NIH HHS/United States K23 AG062400/AG/NIA NIH HHS/United States R01 HD098977/HD/NICHD NIH HHS/United States P30 AI124414/AI/NIAID NIH HHS/United States UL1 TR002556/TR/NCATS NIH HHS/United States

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