Small-molecule inhibitor targeting the Hsp70-Bim protein-protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance.
第一作者:
Ting,Song
第一单位:
State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
作者:
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞增殖(Cell Proliferation);抗药性, 肿瘤(Drug Resistance, Neoplasm);融合蛋白质类, bcr-abl(Fusion Proteins, bcr-abl);基因表达调控, 白血病(Gene Expression Regulation, Leukemic);HSP70热休克蛋白质类(HSP70 Heat-Shock Proteins);人类(Humans);白血病, 髓系, 慢性, BCR-ABL阳性(Leukemia, Myelogenous, Chronic, BCR-ABL Positive);男(雄)性(Male);小鼠(Mice);小鼠, 裸(Mice, Nude);预后(Prognosis);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs);蛋白激酶抑制剂(Protein Kinase Inhibitors);小分子化合物库(Small Molecule Libraries);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1038/s41375-021-01283-5
PMID
34007045
发布时间
2023-02-05
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Leukemia
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