Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.

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第一作者： Zining,Wang

第一单位： State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China xiaxj@sysucc.org.cn wangzn@sysucc.org.cn.

作者： Zining,Wang ^[1] ; Feifei,Xu ^[2] ; Jie,Hu ^[3] ; Hongxia,Zhang ^[2] ; Lei,Cui ^[2] ; Wenhua,Lu ^[2] ; Wenzhuo,He ^[2] ; Xiaojuan,Wang ^[4] ; Mengyun,Li ^[2] ; Huanling,Zhang ^[2] ; Wenjing,Xiong ^[2] ; Chunyuan,Xie ^[2] ; Yongxiang,Liu ^[2] ; Penghui,Zhou ^[2] ; Jinyun,Liu ^[2] ; Peng,Huang ^[2] ; Xiaofeng Frank,Qin ^[5] ; Xiaojun,Xia ^[2]

作者单位： State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China xiaxj@sysucc.org.cn wangzn@sysucc.org.cn. ^[1] State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. ^[2] Department of Medical Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. ^[3] Department of The VIP Region, Sun Yat-sen University Cancer Center, Guangzhou, China. ^[4] Metabolic Innovation Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. ^[5] Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ^[6] Suzhou Institute of Systems Medicine, Suzhou, China. ^[7]

关键词 dendritic cells immunotherapy

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);碱性亮氨酸拉链转录因子类(Basic-Leucine Zipper Transcription Factors);细胞系, 肿瘤(Cell Line, Tumor);克霉唑(Clotrimazole);结肠肿瘤(Colonic Neoplasms);树突细胞(Dendritic Cells);女(雌)性(Female);己糖激酶(Hexokinase);乳酸(Lactic Acid);淋巴细胞活化(Lymphocyte Activation);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);溶酶体(Lysosomes);黑色素瘤, 实验性(Melanoma, Experimental);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小鼠, 裸(Mice, Nude);阻遏蛋白质类(Repressor Proteins);皮肤肿瘤(Skin Neoplasms);T淋巴细胞(T-Lymphocytes);转录因子CHOP(Transcription Factor CHOP);肿瘤负荷(Tumor Burden);肿瘤微环境(Tumor Microenvironment);小鼠(Mice)

DOI 10.1136/jitc-2020-002155

PMID 34016722

发布时间 2024-02-26

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Journal for immunotherapy of cancer

2021年9卷5期

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Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.

Journal for immunotherapy of cancer

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Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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