Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome.
第一作者:
Jiahui,Luo
第一单位:
The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
作者:
医学主题词
动物(Animals);疾病模型, 动物(Disease Models, Animal);基因表达(Gene Expression);基因沉默(Gene Silencing);人类(Humans);炎性体(Inflammasomes);白细胞介素1β(Interleukin-1beta);脂多糖类(Lipopolysaccharides);脂质体(Liposomes);巨噬细胞活化(Macrophage Activation);巨噬细胞(Macrophages);小鼠(Mice);模型, 生物学(Models, Biological);RNA干扰(RNA Interference);RNA, 小分子干扰(RNA, Small Interfering);休克, 脓毒性(Shock, Septic)
DOI
10.3389/fimmu.2021.663295
PMID
34017338
发布时间
2021-10-21
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Frontiers in immunology
663295页
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