The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology.

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作者： Liana G,Apostolova ^[1] ; Paul,Aisen ^[2] ; Ani,Eloyan ^[3] ; Anne,Fagan ^[4] ; Keith N,Fargo ^[5] ; Tatiana,Foroud ^[6] ; Constantine,Gatsonis ^[7] ; Lea T,Grinberg ^[3] ; Clifford R,Jack ^[5] ; Joel,Kramer ^[8] ; Robert,Koeppe ^[9] ; Walter A,Kukull ^[10] ; Melissa E,Murray ^[9] ; Kelly,Nudelman ^[11] ; Malia,Rumbaugh ^[12] ; Arthur,Toga ^[13] ; Prashanthi,Vemuri ^[3] ; Amy,Trullinger ^[3] ; Leonardo,Iaccarino ^[14] ; Gregory S,Day ^[10] ; Neill R,Graff-Radford ^[15] ; Lawrence S,Honig ^[9] ; David T,Jones ^[16] ; Joseph,Masdeu ^[16] ; Mario,Mendez ^[17] ; Erik,Musiek ^[10] ; Chiadi U,Onyike ^[18] ; Emily,Rogalski ^[19] ; Steve,Salloway ^[20] ; David A,Wolk ^[6] ; Thomas S,Wingo ^[21] ; Maria C,Carrillo ^[22] ; Bradford C,Dickerson ^[23] ; Gil D,Rabinovici ^[24] ; LEADS Consortium ^[25]

作者单位： Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA. ^[1] Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA. ^[2] Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA. ^[3] Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA. ^[4] Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA. ^[5] Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA. ^[6] Charcot-Marie Tooth Research Foundation, Naperville, Illinois, USA. ^[7] Department of Pathology, University of California, San Francisco, California, USA. ^[8] Department of Neurology, University of California, San Francisco, California, USA. ^[9] Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA. ^[10] Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA. ^[11] Department of Epidemiology, University of Washington, Seattle, Washington, USA. ^[12] Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA. ^[13] Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, California, USA. ^[14] Indiana Clinical and Translational Sciences Institute, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA. ^[15] Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA. ^[16] Taub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA. ^[17] Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. ^[18] Nantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, Texas, USA. ^[19] Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. ^[20] Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. ^[21] Department of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. ^[22] Department of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA. ^[23] Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[24] Department of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA. ^[25] Medical & Scientific Relations Division, Alzheimer's Association, Chicago, Illinois, USA. ^[26] Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. ^[27]

关键词 Alzheimer's disease EOAD LEADS YOAD early-onset young onset