Microwave-Induced in Situ Drug Amorphization Using a Mixture of Polyethylene Glycol and Polyvinylpyrrolidone.

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第一作者： Nele-Johanna,Hempel

第一单位： Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.

作者： Nele-Johanna,Hempel ^[1] ; Matthias M,Knopp ^[2] ; J Axel,Zeitler ^[3] ; Ragna,Berthelsen ^[1] ; Korbinian,Löbmann ^[4]

作者单位： Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark. ^[1] Bioneer:FARMA, Department of Pharmacy, 2100 Copenhagen, Denmark. ^[2] Department of Chemical Engineering, University of Cambridge, Cambridge CB3 0AS, UK. ^[3] Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address: korbinian.loebmann@sund.ku.dk. ^[4]

关键词 Amorphous solid dispersion Drug loading In situ amorphization Microwave irradiation Polyethylene glycol Ternary phase diagram Transmission Raman spectroscopy

主题词辅药(Excipients);微波(Microwaves);聚乙烯二醇类(Polyethylene Glycols);聚维酮(Povidone);溶解度(Solubility)

DOI 10.1016/j.xphs.2021.05.010

PMID 34022194

发布时间 2021-10-22

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