首页> Journal of hepatology> Linkage of resistance-associated substitutions in GT1 sofosbuvir + NS5A inhibitor failures treated with glecaprevir/pibrentasvir.

Linkage of resistance-associated substitutions in GT1 sofosbuvir + NS5A inhibitor failures treated with glecaprevir/pibrentasvir.

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第一作者： Gary P,Wang

第一单位： Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA; Infectious Disease Section, Medical Service, North Florida/South Georgia Veterans Health System, Gainesville, FL, USA. Electronic address: gary.wang@medicine.ufl.edu.

作者： Gary P,Wang ^[1] ; Gretja L,Schnell ^[2] ; Jens J,Kort ^[3] ; Gurjit S,Sidhu ^[4] ; Layla,Schuster ^[4] ; Rakesh L,Tripathi ^[2] ; Lois,Larsen ^[2] ; Larry C,Michael ^[5] ; Ken,Bergquist ^[5] ; Ashley,Magee ^[5] ; Chandni B,Patel ^[4] ; Joan A,Whitlock ^[4] ; Ryan,Tamashiro ^[4] ; Joy A,Peter ^[6] ; Michael W,Fried ^[7] ; David R,Nelson ^[8]

作者单位： Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA; Infectious Disease Section, Medical Service, North Florida/South Georgia Veterans Health System, Gainesville, FL, USA. Electronic address: gary.wang@medicine.ufl.edu. ^[1] AbbVie Inc, North Chicago, IL, USA. ^[2] AbbVie Inc, Mettawa, IL, USA. ^[3] Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA. ^[4] HCV-Target Data Coordinating Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[5] Hepatology Research, University of Florida, Gainesville, FL, USA. ^[6] Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[7] Department of Medicine, University of Florida, Gainesville, FL, USA. ^[8]

关键词 Glecaprevir/Pibrentasvir Hepatitis C therapy Multiple-linked substitutions NS5A resistance Next-generation sequencing Persistence of treatment-emergent substitutions Resistance-associated substitutions Treatment failure Treatment-emergent RASs