Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies.

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第一作者： Romain,Rouet

第一单位： Immunology Department, Garvan Institute of Medical Research, Sydney, NSW, Australia.

作者： Romain,Rouet ^[1] ; Ohan,Mazigi ^[2] ; Gregory J,Walker ^[1] ; David B,Langley ^[2] ; Meghna,Sobti ^[3] ; Peter,Schofield ^[4] ; Helen,Lenthall ^[1] ; Jennifer,Jackson ^[2] ; Stephanie,Ubiparipovic ^[2] ; Jake Y,Henry ^[5] ; Arunasingam,Abayasingam ^[1] ; Deborah,Burnett ^[2] ; Anthony,Kelleher ^[1] ; Robert,Brink ^[2] ; Rowena A,Bull ^[1] ; Stuart,Turville ^[2] ; Alastair G,Stewart ^[1] ; Christopher C,Goodnow ^[2] ; William D,Rawlinson ^[1] ; Daniel,Christ ^[2]

作者单位： Immunology Department, Garvan Institute of Medical Research, Sydney, NSW, Australia. ^[1] Immunology Department, UNSW Sydney, St Vincent's Clinical School, Sydney, NSW, Australia. ^[2] Immunology Department, UNSW Sydney, Faculty of Medicine, Sydney, NSW, Australia. ^[3] Virology Research Laboratory, Prince of Wales Hospital, Sydney, NSW, Australia. ^[4] Immunology Department, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia. ^[5] Kirby Institute, UNSW Sydney, Sydney, NSW, Australia. ^[6]

关键词 Monoclonal antibodies SARS-CoV-2 antibody engineering antibody maturation phage display structural studies

主题词抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);抗体特异性(Antibody Specificity);交叉反应(Cross Reactions);人类(Humans);诱变, 定点(Mutagenesis, Site-Directed)

DOI 10.1080/19420862.2021.1922134

PMID 34024246

发布时间 2022-12-07

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Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies.

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Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies.

mAbs

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