首页> Journal of medicinal chemistry> Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.

Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.

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第一作者： Darren Le,Grand

第一单位： Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.

作者： Darren Le,Grand ^[1] ; Martin,Gosling ^[1] ; Urs,Baettig ^[1] ; Parmjit,Bahra ^[1] ; Kamlesh,Bala ^[1] ; Cara,Brocklehurst ^[2] ; Emma,Budd ^[1] ; Rebecca,Butler ^[1] ; Atwood K,Cheung ^[3] ; Hedaythul,Choudhury ^[1] ; Stephen P,Collingwood ^[1] ; Brian,Cox ^[1] ; Henry,Danahay ^[1] ; Lee,Edwards ^[1] ; Brian,Everatt ^[1] ; Ulrike,Glaenzel ^[2] ; Anne-Lise,Glotin ^[1] ; Paul,Groot-Kormelink ^[2] ; Edward,Hall ^[3] ; Julia,Hatto ^[1] ; Catherine,Howsham ^[1] ; Glyn,Hughes ^[1] ; Anna,King ^[1] ; Julia,Koehler ^[2] ; Swarupa,Kulkarni ^[4] ; Megan,Lightfoot ^[1] ; Ian,Nicholls ^[2] ; Christopher,Page ^[1] ; Giles,Pergl-Wilson ^[1] ; Mariana Oana,Popa ^[1] ; Richard,Robinson ^[3] ; David,Rowlands ^[3] ; Tom,Sharp ^[1] ; Matthew,Spendiff ^[1] ; Emily,Stanley ^[1] ; Oliver,Steward ^[1] ; Roger J,Taylor ^[1] ; Pamela,Tranter ^[1] ; Trixie,Wagner ^[2] ; Hazel,Watson ^[1] ; Gareth,Williams ^[2] ; Penny,Wright ^[1] ; Alice,Young ^[1] ; David A,Sandham ^[3]

作者单位： Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K. ^[1] Novartis Institutes for Biomedical Research, Novartis Campus, Basel, CH 4002, Switzerland. ^[2] Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States. ^[3] Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936, United States. ^[4]