Depleting plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous lupus.

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作者： Jodi L,Karnell ^[1] ; Yanping,Wu ^[2] ; Nanette,Mittereder ^[2] ; Michael A,Smith ^[2] ; Michele,Gunsior ^[2] ; Li,Yan ^[2] ; Kerry A,Casey ^[3] ; Jill,Henault ^[3] ; Jeffrey M,Riggs ^[3] ; Simone M,Nicholson ^[3] ; Miguel A,Sanjuan ^[3] ; Katherine A,Vousden ^[4] ; Victoria P,Werth ^[5] ; Jörn,Drappa ^[2] ; Gabor G,Illei ^[2] ; William A,Rees ^[2] ; John N,Ratchford ^[2] ; VIB7734 Trial Investigators

作者单位： Viela Bio, Gaithersburg, MD 20878, USA. jkarnell@horizontherapeutics.com. ^[1] Viela Bio, Gaithersburg, MD 20878, USA. ^[2] AstraZeneca, Gaithersburg, MD 20878, USA. ^[3] AstraZeneca, Cambridge CB21 6GH, UK. ^[4] Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[5]

主题词自身免疫(Autoimmunity);炎症趋化因子类(Chemokines);树突细胞(Dendritic Cells);人类(Humans);干扰素Ⅰ型(Interferon Type I);红斑狼疮, 皮肤(Lupus Erythematosus, Cutaneous)

DOI 10.1126/scitranslmed.abf8442

PMID 34039741

发布时间 2022-05-31

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准确一般字义偏差语意偏离译文作用小提交