Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host.

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第一作者： Ouma,Onguka

第一单位： Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

作者： Ouma,Onguka ^[1] ; Brett M,Babin ^[1] ; Markus,Lakemeyer ^[1] ; Ian T,Foe ^[1] ; Neri,Amara ^[1] ; Stephanie M,Terrell ^[2] ; Kenneth M,Lum ^[3] ; Piotr,Cieplak ^[4] ; Micah J,Niphakis ^[3] ; Jonathan Z,Long ^[2] ; Matthew,Bogyo ^[5]

作者单位： Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. ^[1] Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford ChEM-H, Stanford University, Stanford, CA 94305, USA. ^[2] Lundbeck La Jolla Research Center, San Diego, CA 92121, USA. ^[3] Infectious & Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. ^[4] Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. Electronic address: mbogyo@stanford.edu. ^[5]

关键词 CDP-DAG Plasmodium falciparum Toxoplasma gondii cholesterol depalmitoylases lipid metabolism oleic acid phosphatidic acid serine hydrolases α/β-hydrolase superfamily

主题词氨基酸序列(Amino Acid Sequence);催化域(Catalytic Domain);水解作用(Hydrolysis);动力学(Kinetics);脂类代谢(Lipid Metabolism);种系发生(Phylogeny);原虫蛋白质类(Protozoan Proteins);重组蛋白质类(Recombinant Proteins);序列比对(Sequence Alignment);丝氨酸内肽酶类(Serine Endopeptidases);小分子化合物库(Small Molecule Libraries);底物特异性(Substrate Specificity);弓形虫属(Toxoplasma)

DOI 10.1016/j.chembiol.2021.05.001

PMID 34043961

发布时间 2022-10-22

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Cell chemical biology

2021年28卷10期

1501-1513.e5页

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Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host.

Cell chemical biology

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Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host.

Cell chemical biology

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