Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease.

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作者： Li,Zhang ^[1] ; Zhaohong,Qin ^[1] ; Fariba,Sharmin ^[2] ; Wei,Lin ^[1] ; Konrad M,Ricke ^[3] ; Michael A,Zasloff ^[4] ; Alexandre F R,Stewart ^[5] ; Hsiao-Huei,Chen ^[6]

作者单位： Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON K1H8M5, Canada; University of Ottawa Brain and Mind Institute, Ottawa, ON K1H8M5, Canada. ^[1] Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON K1H8M5, Canada; University of Ottawa Brain and Mind Institute, Ottawa, ON K1H8M5, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[2] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada; University of Ottawa Heart Institute, Ottawa, ON K1Y4W7, Canada. ^[3] Georgetown University School of Medicine, MedStar Georgetown Transplant Institute, Washington, DC, 2007, USA. ^[4] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada; University of Ottawa Heart Institute, Ottawa, ON K1Y4W7, Canada. Electronic address: astewart@ottawaheart.ca. ^[5] Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON K1H8M5, Canada; University of Ottawa Brain and Mind Institute, Ottawa, ON K1H8M5, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada; Department of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address: hchen@uottawa.ca. ^[6]

关键词 Cognitive function Hippocampus Long-term potentiation Presynaptic NMDA receptor Short-term facilitation Synaptic plasticity Trodusquemine Tyrosine phosphatase