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首页> International journal of pharmaceutics> Effects of compaction and storage conditions on stability of intravenous immunoglobulin - Implication on developing oral tablets of biologics.

Effects of compaction and storage conditions on stability of intravenous immunoglobulin - Implication on developing oral tablets of biologics.

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第一作者： Yuwei,Lu

第一单位： Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MN 21201, United States.

作者： Yuwei,Lu ^[1] ; Chenguang,Wang ^[2] ; Bowen,Jiang ^[1] ; Changquan Calvin,Sun ^[3] ; Stephen W,Hoag ^[4]

作者单位： Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MN 21201, United States. ^[1] Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, United States. ^[2] Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: sunx0053@umn.edu. ^[3] Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MN 21201, United States. Electronic address: shoag@rx.umaryland.edu. ^[4]

关键词 Aggregation Immunoglobulin Mechanical properties Monoclonal antibody Oral tablet

主题词生物制品(Biological Products);色谱法, 凝胶(Chromatography, Gel);圆二色性(Circular Dichroism);药物稳定性(Drug Stability);人类(Humans);免疫球蛋白类, 静脉内(Immunoglobulins, Intravenous);谱学, 傅里叶变换红外(Spectroscopy, Fourier Transform Infrared);片剂(Tablets)

DOI 10.1016/j.ijpharm.2021.120737

PMID 34048928

发布时间 2021-07-27

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International journal of pharmaceutics

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