A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-Cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data.

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作者： Su,Wang ^[1] ; Stephane,Flibotte ^[2] ; Joan,Camunas-Soler ^[3] ; Patrick E,MacDonald ^[4] ; James D,Johnson ^[5]

作者单位： Diabetes Research Group, Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada. ^[1] Life Sciences Institute Bioinformatics Core Facility, University of British Columbia, Vancouver, British Columbia, Canada. ^[2] Department of Bioengineering, Stanford University, Stanford, California, United States. ^[3] Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Canada. ^[4] Diabetes Research Group, Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada; Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: james.d.johnson@ubc.ca. ^[5]

关键词 ARN-seq unicellulaire VNTR VNTR (de l’anglais, variable number of tandem repeats)diabète de type 1 expression d’insuline genetics génétique insulin expression single-cell RNAseq type 1 diabetes

主题词等位基因(Alleles);糖尿病, 1型(Diabetes Mellitus, Type 1);糖尿病, 2型(Diabetes Mellitus, Type 2);女(雌)性(Female);人类(Humans);胰岛素(Insulin);男(雄)性(Male);小卫星重复(Minisatellite Repeats);RNA, 信使(RNA, Messenger)

DOI 10.1016/j.jcjd.2021.03.007

PMID 34052132

发布时间 2022-01-13

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Canadian journal of diabetes

2021年45卷8期

775-784.e2页

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A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-Cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data.

Canadian journal of diabetes

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Canadian journal of diabetes

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A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-Cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data.

Canadian journal of diabetes

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Canadian journal of diabetes

相关期刊

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