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Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor.

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第一作者： Malcolm P,Huestis

第一单位： Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

作者： Malcolm P,Huestis ^[1] ; Matthew R,Durk ^[2] ; Charles,Eigenbrot ^[3] ; Paul,Gibbons ^[1] ; Thomas L,Hunsaker ^[4] ; Hank,La ^[2] ; Dennis H,Leung ^[5] ; Wendy,Liu ^[1] ; Shiva,Malek ^[6] ; Mark,Merchant ^[4] ; John G,Moffat ^[7] ; Christine S,Muli ^[5] ; Christine J,Orr ^[4] ; Brendan T,Parr ^[1] ; Frances,Shanahan ^[6] ; Christopher J,Sneeringer ^[7] ; Weiru,Wang ^[3] ; Ivana,Yen ^[6] ; Jianping,Yin ^[3] ; Joachim,Rudolph ^[1] ; Michael,Siu ^[1]

作者单位： Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[1] Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[2] Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[3] Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[4] Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[5] Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[6] Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[7]

DOI 10.1021/acsmedchemlett.1c00063

PMID 34055227

发布时间 2022-05-14

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