Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation.

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作者： Philipp J,Hohensinner ^[1] ; Max,Lenz ^[2] ; Patrick,Haider ^[2] ; Julia,Mayer ^[3] ; Manuela,Richter ^[3] ; Christoph,Kaun ^[2] ; Laura,Goederle ^[4] ; Mira,Brekalo ^[2] ; Manuel,Salzmann ^[2] ; Smriti,Sharma ^[2] ; Michael B,Fischer ^[5] ; Stefan,Stojkovic ^[2] ; Daniel,Ramsmayer ^[2] ; Christian,Hengstenberg ^[2] ; Bruno K,Podesser ^[6] ; Kurt,Huber ^[7] ; Christoph J,Binder ^[4] ; Johann,Wojta ^[8] ; Walter S,Speidl ^[2]

作者单位： Department of Internal Medicine II/Cardiology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria; Center for Biomedical Research, Medical University of Vienna, Vienna, Austria. ^[1] Department of Internal Medicine II/Cardiology, Medical University of Vienna, Vienna, Austria. ^[2] Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria. ^[3] Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. ^[4] Clinic for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria; Department for Health Science and Biomedicine, Danube University Krems, Krems, Austria. ^[5] Center for Biomedical Research, Medical University of Vienna, Vienna, Austria. ^[6] 3(rd) Medical Department, Wilhelminenhospital, Vienna, Austria; Sigmund Freud University, Medical Faculty, Vienna, Austria. ^[7] Department of Internal Medicine II/Cardiology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria; Core Facilities, Medical University of Vienna, Vienna, Austria. Electronic address: johann.wojta@meduniwien.ac.at. ^[8]

主题词动物(Animals);动脉粥样硬化(Atherosclerosis);细胞因子类(Cytokines);脂肪酸类(Fatty Acids);基因表达调控(Gene Expression Regulation);人类(Humans);炎性体(Inflammasomes);脂类代谢(Lipid Metabolism);巨噬细胞(Macrophages);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);氧化还原(Oxidation-Reduction);受体, LDL(Receptors, LDL);曲美他嗪(Trimetazidine);血管舒张药(Vasodilator Agents)

DOI 10.1016/j.bcp.2021.114634

PMID 34058186

发布时间 2021-11-17

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Biochemical pharmacology

2021年190卷

114634页

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Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation.

Biochemical pharmacology

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Biochemical pharmacology

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Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation.

Biochemical pharmacology

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Biochemical pharmacology

相关期刊

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