Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid.

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作者： Keisuke,Sato ^[1] ; Kyoko,Yamazaki ^[2] ; Tamotsu,Kato ^[1] ; Yumiko,Nakanishi ^[2] ; Takahiro,Tsuzuno ^[3] ; Mai,Yokoji-Takeuchi ^[3] ; Miki,Yamada-Hara ^[4] ; Nobuaki,Miura ^[1] ; Shujiro,Okuda ^[2] ; Hiroshi,Ohno ^[2] ; Kazuhisa,Yamazaki ^[2]

作者单位： Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan. ^[1] Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan. ^[2] Laboratory for Intestinal Ecosystem, RIKEN Centre for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan. ^[3] Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki, Japan. ^[4] Division of Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan. ^[5]

关键词 gut microbiome metabolomics obesity periodontal disease uric acid