Short interfering RNA delivered by a hybrid nanoparticle targeting VEGF: Biodistribution and anti-tumor effect.

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作者： Gabriela Regina Rosa,Souza ^[1] ; Milene,Dalmina ^[1] ; Jelver Alexander Sierra,Restrepo ^[2] ; Leônidas João,de Mello Junior ^[3] ; Adny Henrique,Silva ^[1] ; Ana,Gualberto ^[4] ; Jacy,Gameiro ^[4] ; Dalton,Dittz ^[5] ; André Avelino,Pasa ^[2] ; Frederico,Pittella ^[6] ; Tânia Beatriz,Creczynski-Pasa ^[7]

作者单位： Department of Pharmaceutical Sciences, Federal University of Santa Catarina, SC, Brazil. ^[1] Graduate Program in Materials Science and Engineering, Department of Physics, Federal University of Santa Catarina, SC, Brazil. ^[2] Department of Biochemistry, Federal University of Santa Catarina, SC, Brazil. ^[3] Graduate Program in Biological Sciences, Federal University of Juiz de Fora, MG, Brazil. ^[4] Department of Pharmacology, Federal University of Minas Gerais, MG, Brazil. ^[5] Department of Pharmaceutical Sciences, Graduate Program in Biological Sciences, Federal University of Juiz de Fora, MG, Brazil. ^[6] Department of Pharmaceutical Sciences, Federal University of Santa Catarina, SC, Brazil. Electronic address: tania.pasa@ufsc.br. ^[7]

关键词 Breast cancer treatment Gene silence Hybrid nanoparticles RNA interference Tumor reduction

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);纳米粒子(Nanoparticles);粒子大小(Particle Size);RNA, 小分子干扰(RNA, Small Interfering);血管内皮生长因子A(Vascular Endothelial Growth Factor A)

DOI 10.1016/j.bbagen.2021.129938

PMID 34062235

发布时间 2021-11-16

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Biochimica et biophysica acta. General subjects

2021年1865卷9期

129938页

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Short interfering RNA delivered by a hybrid nanoparticle targeting VEGF: Biodistribution and anti-tumor effect.

Biochimica et biophysica acta. General subjects

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Biochimica et biophysica acta. General subjects

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Short interfering RNA delivered by a hybrid nanoparticle targeting VEGF: Biodistribution and anti-tumor effect.

Biochimica et biophysica acta. General subjects

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Biochimica et biophysica acta. General subjects

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