Randomised phase 2 study comparing the efficacy and safety of the oral tyrosine kinase inhibitor nintedanib with single agent ifosfamide in patients with advanced, inoperable, metastatic soft tissue sarcoma after failure of first-line chemotherapy: EORTC-1506-STBSG "ANITA".

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第一作者： Patrick,Schöffski

第一单位： Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium; Department of Oncology, KU Leuven, Laboratory of Experimental Oncology, Leuven, Belgium. Electronic address: patrick.schoffski@uzleuven.be.

作者： Patrick,Schöffski ^[1] ; Maud,Toulmonde ^[2] ; Anna,Estival ^[3] ; Gloria,Marquina ^[4] ; Monika,Dudzisz-Śledź ^[5] ; Mehdi,Brahmi ^[6] ; Neeltje,Steeghs ^[7] ; Vasilios,Karavasilis ^[8] ; Jacco,de Haan ^[9] ; Agnieszka,Wozniak ^[10] ; Sophie,Cousin ^[2] ; Marta,Domènech ^[3] ; Judith V M G,Bovée ^[11] ; Céline,Charon-Barra ^[12] ; Sandrine,Marreaud ^[13] ; Saskia,Litière ^[13] ; Laura,De Meulemeester ^[13] ; Christine,Olungu ^[13] ; Hans,Gelderblom ^[14]

作者单位： Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium; Department of Oncology, KU Leuven, Laboratory of Experimental Oncology, Leuven, Belgium. Electronic address: patrick.schoffski@uzleuven.be. ^[1] Sarcoma Unit, Institut Bergonié, Bordeaux, France. ^[2] Department of Medical Oncology, Catalan Institute of Oncology (ICO) Badalona / Hospital Germans Trias I Pujol. B-ARGO, Barcelona, Spain. ^[3] Department of General Medical Oncology, Hospital Clinico San Carlos, Madrid, Spain. ^[4] Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. ^[5] Centre Léon Bérard, Université Cl. Bernard Lyon 1, Lyon, France. ^[6] Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands. ^[7] University College Hospital, London, United Kingdom. ^[8] University Medical Center, Groningen, the Netherlands. ^[9] Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium; Department of Oncology, KU Leuven, Laboratory of Experimental Oncology, Leuven, Belgium. ^[10] Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. ^[11] Department of Pathology, Centre Georges-François Leclerc, Dijon, France. ^[12] European Organization for Research and Treatment of Cancer, Brussels, Belgium. ^[13] Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands. ^[14]

关键词 Chemotherapy Fibroblast growth factor receptor Ifosfamide Nintedanib Oral anticancer treatment Soft tissue sarcoma Tyrosine kinase inhibitor Vascular endothelial growth factor receptor