PI3K/mTOR Dual Inhibitor PF-04691502 Is a Schedule-Dependent Radiosensitizer for Gastroenteropancreatic Neuroendocrine Tumors.

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作者： Zeta,Chow ^[1] ; Jeremy,Johnson ^[2] ; Aman,Chauhan ^[1] ; Tadahide,Izumi ^[1] ; Michael,Cavnar ^[3] ; Heidi,Weiss ^[1] ; Courtney M,Townsend ^[4] ; Lowell,Anthony ^[1] ; Carrigan,Wasilchenko ^[2] ; Matthew L,Melton ^[1] ; Jörg,Schrader ^[5] ; B Mark,Evers ^[6] ; Piotr,Rychahou ^[1]

作者单位： Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA. ^[1] Department of Surgery, University of Kentucky, Lexington, KY 40536, USA. ^[2] Department of Internal Medicine, Division of Medical Oncology, University of Kentucky, Lexington, KY 40536, USA. ^[3] Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA. ^[4] Department of Internal Medicine, Division of Cancer Biostatistics, University of Kentucky, Lexington, KY 40536, USA. ^[5] Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA. ^[6] Medical Department and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany. ^[7]

关键词 PI3K inhibitor neuroendocrine tumor radiosensitization

主题词细胞凋亡(Apoptosis);细胞增殖(Cell Proliferation);人类(Humans);肠肿瘤(Intestinal Neoplasms);神经内分泌瘤(Neuroendocrine Tumors);胰腺肿瘤(Pancreatic Neoplasms);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);吡啶酮类(Pyridones);嘧啶类(Pyrimidines);辐射增敏药(Radiation-Sensitizing Agents);胃肿瘤(Stomach Neoplasms);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);肿瘤细胞, 培养的(Tumor Cells, Cultured)

DOI 10.3390/cells10051261

PMID 34065268

发布时间 2022-07-16

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2021年10卷5期

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PI3K/mTOR Dual Inhibitor PF-04691502 Is a Schedule-Dependent Radiosensitizer for Gastroenteropancreatic Neuroendocrine Tumors.

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PI3K/mTOR Dual Inhibitor PF-04691502 Is a Schedule-Dependent Radiosensitizer for Gastroenteropancreatic Neuroendocrine Tumors.

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