Histone Deacetylase Inhibitors Ameliorate Morphological Defects and Hypoexcitability of iPSC-Neurons from Rubinstein-Taybi Patients.

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第一作者： Valentina,Alari

第一单位： Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.

作者： Valentina,Alari ^[1] ; Paolo,Scalmani ^[2] ; Paola Francesca,Ajmone ^[3] ; Sara,Perego ^[1] ; Sabrina,Avignone ^[4] ; Ilaria,Catusi ^[1] ; Paola Adele,Lonati ^[5] ; Maria Orietta,Borghi ^[5] ; Palma,Finelli ^[6] ; Benedetta,Terragni ^[1] ; Massimo,Mantegazza ^[7] ; Silvia,Russo ^[2] ; Lidia,Larizza ^[2]

作者单位： Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy. ^[1] Department of Neurophysiology and Diagnostic Epileptology, IRCCS Foundation C. Besta Neurological Institute, 20133 Milan, Italy. ^[2] Child and Adolescent Neuropsychiatric Service (UONPIA), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. ^[3] Department of Neuroradiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. ^[4] Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy. ^[5] Immunorheumatology Research Laboratory, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy. ^[6] Department of Medical Biotechnology and Translational Medicine, University of Milan, 20133 Milan, Italy. ^[7] Institute of Molecular and Cellular Pharmacology (IPMC), CNRS UMR7275, Inserm, LabEx ICST, Université Cote d'Azur (UCA), Sophia Antipolis, 06560 Valbonne, France. ^[8]

关键词 Rubinstein-Taybi histone deacetylase inhibitors hypoexcitability iPSC-neurons intellectual disability morphological abnormalities partial rescue trichostatin A valproic acid