Dysregulation of Muscle-Specific MicroRNAs as Common Pathogenic Feature Associated with Muscle Atrophy in ALS, SMA and SBMA: Evidence from Animal Models and Human Patients.

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作者： Claudia,Malacarne ^[1] ; Mariarita,Galbiati ^[2] ; Eleonora,Giagnorio ^[3] ; Paola,Cavalcante ^[1] ; Franco,Salerno ^[2] ; Francesca,Andreetta ^[1] ; Cinza,Cagnoli ^[1] ; Michela,Taiana ^[1] ; Monica,Nizzardo ^[4] ; Stefania,Corti ^[5] ; Viviana,Pensato ^[6] ; Anna,Venerando ^[5] ; Cinzia,Gellera ^[6] ; Silvia,Fenu ^[7] ; Davide,Pareyson ^[7] ; Riccardo,Masson ^[7] ; Lorenzo,Maggi ^[8] ; Eleonora,Dalla Bella ^[8] ; Giuseppe,Lauria ^[9] ; Renato,Mantegazza ^[1] ; Pia,Bernasconi ^[10] ; Angelo,Poletti ^[10] ; Silvia,Bonanno ^[11] ; Stefania,Marcuzzo ^[1]

作者单位： Neurology IV-Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy. ^[1] PhD Program in Neuroscience, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. ^[2] Dipartimento di Scienze Farmacologiche e Biomolecolari, Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Via Balzaretti, 9, 20133 Milano, Italy. ^[3] Molecular Neuroanatomy and Pathogenesis Unit, Neurology VII-Clinical and Experimental Epileptology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy. ^[4] Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy. ^[5] Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. ^[6] Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy. ^[7] Unit of Rare Neurodegenerative and Neurometabolic Diseases, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy. ^[8] Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy. ^[9] Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy. ^[10] Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Via G.B. Grassi 74, 20157 Milan, Italy. ^[11]

关键词 amyotrophic lateral sclerosis motor neuron diseases mouse models muscle-specific microRNAs spinal bulbar muscular atrophy spinal muscular atrophy